GLYCINE METHYLTRANSFERASE
- 1 January 1963
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry and Physiology
- Vol. 41 (1), 201-210
- https://doi.org/10.1139/y63-025
Abstract
The supernatant fraction of liver homogenate brings about the methylation of glycine by S-adenosylmethionine. The secondary amine formed in the reaction appears to be sarcosine. This conclusion is based on (I) the stoichiometry of the reaction, and (II) radio-autography of chromatograms of the incubation products. The enzyme, glycine N-methyltransferase, was purified 80-fold, and certain of its characteristics are reported. The possible role of the enzyme in the biological oxidation of the methyl group of methionine is discussed.Keywords
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