Macrophage-Targeted Overexpression of Urokinase Causes Accelerated Atherosclerosis, Coronary Artery Occlusions, and Premature Death
- 4 May 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 109 (17), 2129-2135
- https://doi.org/10.1161/01.cir.0000127369.24127.03
Abstract
Background— Human atherosclerotic lesions contain elevated levels of urokinase plasminogen activator (uPA), expressed predominantly by macrophages. Methods and Results— To test the hypothesis that ...Keywords
This publication has 25 references indexed in Scilit:
- ApoE knockout mice expressing human matrix metalloproteinase-1 in macrophages have less advanced atherosclerosisJournal of Clinical Investigation, 2001
- Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formationNature Genetics, 1997
- Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100.Journal of Clinical Investigation, 1997
- Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion.Journal of Clinical Investigation, 1995
- Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.Genes & Development, 1995
- Production of Second Messengers Following Chemotactic and Mitogenic Urokinase-Receptor Interaction in Human Fibroblasts and Mouse Fibroblasts Transfected with Human Urokinase ReceptorExperimental Cell Research, 1994
- Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells.The Journal of cell biology, 1994
- Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activatorCell, 1990
- Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.The Journal of cell biology, 1990
- The murine urokinase-type plasminogen activator geneBiochemistry, 1987