A study of 24 patients suffering from cutaneous amyloidosis was made. In 9 cases of 13 studied, an association with diseases of a constitutional or allergic nature such as asthma, neurodermatitis, vasomotor rhinitis and allergic conjunctivitis was found. Family studies of 13 of the cases showed the occurrence of diseases of constitutional and allergic nature in the members of 7 families. The findings suggest that cutaneous amyloidosis may be regarded as a constitutional disorder belonging to the group of atopic diseases.