Nonsteroidal anti-inflammatory drugs and gastrointestinal bleeding. A case-control study
- 1 December 1986
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 146 (12), 2365-2367
- https://doi.org/10.1001/archinte.146.12.2365
Abstract
This study looked at the association between nonsteroidal anti-inflammatory drug (NSAID) use and acute nonvariceal upper gastrointestinal tract bleeding (AUGIB). Fifty-seven consecutive patients presenting to hospital with AUGIB were compared with 123 sex- and age-matched controls. Twenty-four (42.1%) of the 57 AUGIB patients were taking NSAIDs compared with 23 (18.1%) of the 123 control subjects. Patients whose AUGIB was associated with NSAID use were significantly older than the group whose bleeding was not associated with drug use; no other differences between these two groups was found. Seventy percent of patients taking nonacetylsalicyclic acid who developed bleeding in this study did so within three months of starting therapy. Abdominal pain was an infrequent presenting complaint.This publication has 5 references indexed in Scilit:
- Non-steroidal anti-inflammatory drugs and peptic ulcer perforation.Gut, 1985
- Naproxen pharmacokinetics in the elderly.British Journal of Clinical Pharmacology, 1984
- Effect of indomethacin on basal and histamine stimulated human gastric acid secretion.Gut, 1984
- Genetic predictors of patient response and side effects in the treatment of rheumatoid arthritis with a high dose nonsteroidal antiinflammatory drug regimenArthritis & Rheumatism, 1982
- A DOUBLE-BLIND RANDOMIZED PLACEBO CONTROLLED GASTROSCOPIC STUDY TO COMPARE THE EFFECTS OF INDOMETHACIN CAPSULES AND INDOMETHACIN SUPPOSITORIES ON THE GASTRIC-MUCOSA OF HUMAN VOLUNTEERS1982