Core outcome sets in dermatology: report from the second meeting of the International Cochrane Skin Group Core Outcome Set Initiative
- 14 February 2018
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Dermatology
- Vol. 178 (4), e279-e285
- https://doi.org/10.1111/bjd.16324
Abstract
Results of clinical trials are the most important information source for generating external clinical evidence. The use of different outcomes across trials, which investigate similar interventions for similar patient groups, significantly limits the interpretation, comparability and clinical application of trial results. Core outcome sets (COSs) aim to overcome this limitation. A COS is an agreed standardized collection of outcomes that should be measured and reported in all clinical trials for a specific clinical condition. The Core Outcome Set Initiative within the Cochrane Skin Group (CSG‐COUSIN) supports the development of core outcomes in dermatology. In the second CSG‐COUSIN meeting held in 2017, 11 COS development groups working on skin diseases presented their current work. The presentations and discussions identified the following overarching methodological challenges for COS development in dermatology: it is not always easy to define the disease focus of a COS; the optimal method for outcome domain identification and level of detail needed to specify such domains is challenging to many; decision rules within Delphi surveys need to be improved; appropriate ways of patient involvement are not always clear. In addition, there appear to be outcome domains that may be relevant as potential core outcome domains for the majority of skin diseases. The close collaboration between methodologists in the Core Outcome Set Initiative and the international Cochrane Skin Group has major advantages for trialists, systematic reviewers and COS developers.Funding Information
- National Institute for Health Research
This publication has 35 references indexed in Scilit:
- Developing core outcome sets for clinical trials: issues to considerTrials, 2012
- GRADE guidelines: 2. Framing the question and deciding on important outcomesJournal of Clinical Epidemiology, 2011
- Core Outcome Domains for Controlled Trials and Clinical Recordkeeping in Eczema: International Multiperspective Delphi Consensus ProcessJournal of Investigative Dermatology, 2011
- Using the Delphi Technique to Determine Which Outcomes to Measure in Clinical Trials: Recommendations for the Future Based on a Systematic Review of Existing StudiesPLoS Medicine, 2011
- Harmonising Outcome Measures for Eczema (HOME).Report from the First International Consensus Meeting (HOME 1), 24 July 2010, Munich, GermanyBritish Journal of Dermatology, 2010
- How Good Are Clinical Severity and Outcome Measures for Psoriasis?: Quantitative Evaluation in a Systematic ReviewJournal of Investigative Dermatology, 2010
- Assessing Risk of Bias in Included StudiesPublished by Wiley ,2008
- Standardising outcomes for clinical trials and systematic reviewsTrials, 2007
- What are the best outcome measurements for atopic eczema? A systematic reviewJournal of Allergy and Clinical Immunology, 2007
- Systematic reviews in health care: Assessing the quality of controlled clinical trialsBMJ, 2001