Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma.
Open Access
- 1 November 1976
- journal article
- research article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 58 (5), 1119-1122
- https://doi.org/10.1172/jci108564
Abstract
During the incubation of arachidonic acid with platelet-rich plasma, a persistent activity appeared that caused the release of [14C]5-hydroxytryptamine from indomethacin-treated platelets. By the time-course of its appearance and disappearance, this release-inducing activity could be dissociated from prostaglandin endoperoxides and associated with thromboxane A2-like material. This material persists in plasma because of its continued production and increased stability.This publication has 8 references indexed in Scilit:
- Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.Proceedings of the National Academy of Sciences, 1975
- Physiological role of an endoperoxide in human platelets: hemostatic defect due to platelet cyclo-oxygenase deficiency.Proceedings of the National Academy of Sciences, 1975
- Prostaglandins and Precursors in Platelet FunctionPublished by Wiley ,1975
- Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human PlateletsProceedings of the National Academy of Sciences, 1974
- Formation of an Intermediate in Prostaglandin Biosynthesis and Its Association with the Platelet Release ReactionJournal of Clinical Investigation, 1974
- Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet AggregationProceedings of the National Academy of Sciences, 1974
- Arachidonic acid-induced human platelet aggregation and prostaglandin formationProstaglandins, 1973
- Effects of normal and aspirin platelets on defective secondary aggregation in the Hermansky-Pudlak syndrome. A test for storage pool deficient platelets.1972