A Conserved p38 MAP Kinase Pathway in Caenorhabditis elegans Innate Immunity
Top Cited Papers
- 26 July 2002
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 297 (5581), 623-626
- https://doi.org/10.1126/science.1073759
Abstract
A genetic screen for Caenorhabditis elegans mutants with enhanced susceptibility to killing by Pseudomonas aeruginosaled to the identification of two genes required for pathogen resistance: sek-1, which encodes a mitogen-activated protein (MAP) kinase kinase, and nsy-1, which encodes a MAP kinase kinase kinase. RNA interference assays and biochemical analysis established that a p38 ortholog, pmk-1, functions as the downstream MAP kinase required for pathogen defense. These data suggest that this MAP kinase signaling cassette represents an ancient feature of innate immune responses in evolutionarily diverse species.Keywords
This publication has 21 references indexed in Scilit:
- MAP kinase signalling cascade in Arabidopsis innate immunityNature, 2002
- SEK‐1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegansEMBO Reports, 2002
- Isolation and Characterization of pmk-(1–3): Three p38 Homologs in Caenorhabditis elegansMolecular Cell Biology Research Communications, 2001
- jkk-1 and mek-1 regulate body movement coordination and response to heavy metals through jnk-1 in Caenorhabditis elegansThe EMBO Journal, 2001
- A simple model host for identifying Gram-positive virulence factorsProceedings of the National Academy of Sciences, 2001
- Mutations in the Drosophila dTAK1 gene reveal a conserved function for MAPKKKs in the control of rel/NF-κB-dependent innate immune responsesGenes & Development, 2001
- Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism mapNature Genetics, 2001
- Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium -mediated killingProceedings of the National Academy of Sciences, 2001
- Phylogenetic Perspectives in Innate ImmunityScience, 1999
- A JNK signal transduction pathway that mediates morphogenesis and an immune response in Drosophila.Genes & Development, 1996