A Mechanism for the Copper-Molybdenum Interrelationship

Abstract

The in vivo response of liver sulfide oxidase to a number of nutritional stimuli is reported. The decreased level of the enzyme accompanying molybdate toxicity was attributable largely to the decreased food intake of the animals. Evidence was presented to indicate a dependence of the enzyme upon copper and an adjustment of enzyme activity to substrate level. The results were discussed in terms of a postulated role for the enzyme in the induction of copper deficiency by toxic levels of molybdate.