The Distribution and Excretion by Cats of A New Hypotensive Drug, N-Benzyl-N′N″-Dimethylguanidine
- 1 September 1962
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 14 (1), 722-726
- https://doi.org/10.1111/j.2042-7158.1962.tb11166.x
Abstract
The distribution and excretion of 14C-labelled N-benzyl-N′N″-dimethylguanidine (BW 467C60) have been studied in cats. The drug, like bretylium, had a selective affinity for adrenergic neurones. At 3 mg./kg., about half the dose was excreted unchanged in urine within 24 hr. and no metabolites were found. Excretion continued for more than 7 days.Keywords
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