13C Nuclear Magnetic Resonance and Circular Dichroism Studies of the Tuftsin Conformation in Water
- 1 November 1980
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 112 (2), 339-343
- https://doi.org/10.1111/j.1432-1033.1980.tb07210.x
Abstract
13C-NMR and circular dichroic (CD) spectra of tuftsin and its analogues are discussed in connection with the hypothesis that the .beta.-turn is the biologically active conformation of tuftsin. The changes in CD spectra evoked by an increase in pH are interpreted as a demonstration of the increasing amount of .beta.-turn conformers in solution. Configurational changes in successive residues of tuftsin showed that residues 2 and 3 of the peptide chain are important for the tuftsin conformation.This publication has 16 references indexed in Scilit:
- Nuclear magnetic resonance studies on the structure of the tetrapeptide tuftsin L-threonyl-L-lysyl-L-prolyl-L-arginine, and its pentapeptide analog L-threonyl-L-lysyl-L-prolyl-L-prolyl-L-arginineBiochemistry, 1979
- Influence of hydration on the conformational stability and formation of bends in terminally blocked dipeptidesBiopolymers, 1979
- Circular dichroism of β turns in peptides and proteinsBiochemistry, 1978
- PARTIAL SEQUENCES OF HISTONES WITH TUFTSIN ACTIVITYInternational Journal of Peptide and Protein Research, 1977
- Peptide conformation. Evidence for .beta. structures in solutions of linear tetrapeptides containing prolineJournal of the American Chemical Society, 1975
- Einfluß der Distanz des Prolincarbonyls vom β- und γ-Kohlenstoff auf die Lage der13C-NMR-SignaleAngewandte Chemie, 1975
- Carbon-13 magnetic resonance spectroscopy. Spectrum of proline in oligopeptidesThe Journal of Organic Chemistry, 1973
- Computed circular dichroism spectra for the evaluation of protein conformationBiochemistry, 1969
- Nuclear magnetic resonance spectroscopy. Carbon-13 spectra of aliphatic carboxylic acids and carboxylate anionsJournal of the American Chemical Society, 1969
- Stereochemical criteria for polypeptides and proteins. V. Conformation of a system of three linked peptide unitsBiopolymers, 1968