Notizen: Hydroxylamin-Empfindlichkeit des Newcastle Disease-Virus (NDV)

Abstract

On the basis of the findings described, the surmise that the different sensitivities to hydroxylamine (NH2OH) can be used to distinguish the influenza virus from the NDV, mumps, and the parainfluenza subgroups of the myxoviruses can no longer be maintained. Electron microscopic studies show that there is no essential difference between the inner components of the "Baudette" and "Italian" strains of NDV; nevertheless the two strains behave differently basically toward NH2OH. For this reason the assumption that the composition of the covering material of these viruses determines whether or not hydroxylamine can react with the ribonucleic acid of the virus is justified. Results reported by other investigators indicate that there are differences in the composition of the covering material of individual NDV strains. If this hypothesis is correct, the behavior of the different myxoviruses toward NH2OH would yield evidence as to where they are formed in the cells of the host.