Susceptibility of phosphonoformic acid-resistant herpes simplex virus variants to arabinosylnucleosides and aphidicolin
Open Access
- 1 June 1983
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 23 (6), 914-917
- https://doi.org/10.1128/aac.23.6.914
Abstract
A plaque-reduction assay was used to examine the susceptibility of five phosphonoformic acid-resistant variants of herpes simplex virus type 1 to arabinosylnucleosides and aphidicolin. These viruses were cross-resistant to arabinosylhypoxanthine and to arabinosyladenine when tested in the absence of deoxycoformycin, a deaminase inhibitor. In the presence of deoxycoformycin, no cross-resistance between arabinosyladenine and phosphonoformic acid was observed. The two variants tested were cross-resistant to arabinosylthymine, and all five variants were collaterally susceptible to aphidicolin inhibition.This publication has 24 references indexed in Scilit:
- Effect of combinations of acyclovir with vidarabine or its 5'-monophosphate on herpes simplex viruses in cell culture and in miceAntimicrobial Agents and Chemotherapy, 1982
- Herpes simplex virus variants restraint to high concentrations of acyclovir exist in clinical isolatesAntimicrobial Agents and Chemotherapy, 1982
- Isolation and Characterization of Acyclovir-resistant Mutants of Herpes Simplex VirusJournal of General Virology, 1980
- Aranucleosides and aranucleotides in viral chemotherapyPharmacology & Therapeutics, 1979
- Characteristics of Herpesvirus Mutants Resistant to Phosphonoformate and PhosphonoacetateAntimicrobial Agents and Chemotherapy, 1979
- Antiviral Activity of Arabinosylthymine in Herpesviral Replication: Mechanism of Action In Vivo and In VitroAntimicrobial Agents and Chemotherapy, 1977
- Antiviral Activity of Arabinosyladenine and Arabinosylhypoxanthine in Herpes Simplex Virus-Infected KB Cells: Selective Inhibition of Viral Deoxyribonucleic Acid Synthesis in the Presence of an Adenosine Deaminase InhibitorAntimicrobial Agents and Chemotherapy, 1976
- Antiviral Activity of Arabinosyladenine and Arabinosylhypoxanthine in Herpes Simplex Virus-Infected KB Cells: Selective Inhibition of Viral Deoxyribonucleic Acid Synthesis in Synchronized Suspension CulturesAntimicrobial Agents and Chemotherapy, 1976
- Deoxyribonucleotide metabolism in herpes simplex virus infected HeLa cellsBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1975
- Antiviral Effects of Aphidicolin, a New Antibiotic Produced by Cephalosporium aphidicolaAntimicrobial Agents and Chemotherapy, 1973