Effect of the Antiestrogen Nafoxidine on the Occurrence of Estrogen-Dependent Renal Tumors in Hamster

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Abstract
Chronic treatment with diethylstilbestrol (DES) and polydiethylstilbestrol phosphate produces renal tumors in male hamsters. The antiestrogen nafoxidine administered simultaneously with DES completely inhibits tumor formation. Hepatic glucuronyltransferase activity towards DES decreases in hamsters treated chronically with DES; in hamsters treated with DES and nafoxidine the activity is not modified. The presence of renal tumor results in an increase of activity.