EXPERIMENTS ON THE HYPOTHALAMIC NUCLEI IN THE REGULATION OF CHLORIDE AND SUGAR METABOLISM

Abstract

In 33 cats the paroptic ganglion, the periventricular nucleus or both were unilaterally stimulated and destroyed with help of the Clarke-Horsley stereotaxic apparatus. Blood and urine chloride and blood sugar were examined and the localization of the lesion followed up in histologic series. Lesions of the paroptic ganglion increased blood chloride, lesions of the periventricular nucleus increased blood sugar. The salt metabolism in these hypothalamic lesions was hyperchloremic and hypochloruric. Shape and time relation of blood chloride and sugar curves after hypothalamic lesions differed entirely from those after piqure of oblongata or cerebellar vermis. Blood chloride tolerance curves were lower, blood sugar tolerance curves higher and both slower after the respective hypothalamic lesions.