Non-persisting dyes in anaphylactic investigation.

Abstract

A rapidly eliminated vital dye, available under the names Coomassie blue (CB) and Fast Cyanine (FC), has been found suitable for the demonstration of local anaphylactic reactions in mice and guinea-pigs. Like other dyes used for this purpose, circulating CB/FC does not readily escape through the blood vessel walls except at sites of increased capillary permeability, as in local anaphylaxis. The blue-mauve colour obtained with CB/FC is almost as vivid as that given by Pontamine Sky blue, and is as sensitive an indicator of both cutaneous and pinnal anaphylaxis.