Identification of a common antigen of herpes simplex virus bovine herpes mammillitis virus, and B virus

Abstract

In immunoelectrophoretic analyses 1 common antigen was demonstrated in antigen preparations from herpes simplex virus types 1- and 2- (HSV-1 and HSV-2), bovine herpes mammillitis (BHM) virus and B virus-infected [human epidermoid carcinoma HEp-2 and rabbit kidney] cells solubilized by Triton X-100. The antigen was also demonstrated in solubilized purified HSV-1 and BHM virus. The common antigen was identified as antigen 11 of HSV-1 or HSV-2. Differences were found in the polypeptide composition of the related antigens when isolated from the 4 different herpesviruses, but a glycopolypeptide with a MW of 125,000 was present in each of the 4 different antigen preparations, indicating that this polypeptide carried the common antigenic determinants.