The Effect of Pregnant Mare Serum Hormone on a Case of Primary Hypo-ovarianism

Abstract

A 16-yr.-old [female], with delayed and arrested ovarian development, was treated with PMS hormone (Anteron, Schering). The resumption of sexual development which followed was sufficient to produce the menarche after 5 mos. of cyclic treatment. Treatment was discontinued at that time. Observations since (16 mos.) reveal that the menses remained regular and normal, excessive linear growth was curbed, and secondary sexual characteristics continued to develop. The signs and symptoms of eunuchoid hypo-ovarianism are attributed to the absence of follicular activity in ovaries with a resultant absence of estrogen. Causes are discussed and do not include a deficiency of pituitary gonadotrophic hormone. The synchronization of ovarian development and body growth are necessary during the prepubertal period. Signs of deviations from normal can be found in a study of linear growth, secondary sexual characteristics, and above all in watching for alterations in the character of the vaginal smears.