Antibiotic Prophylaxis in Acute Nonperforated Appendicitis
- 1 March 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Annals of Surgery
- Vol. 209 (3), 307-311
- https://doi.org/10.1097/00000658-198903000-00010
Abstract
In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into three groups: patients with a normal appendix, patients with an acutely inflamed appendix, and patients with a gangrenous appendix. The study showed for each group a significant reduction of the incidence of wound infection in patients receiving prophylaxis. However, intra-abdominal abscess formation was not influenced by preoperative antibiotic prophylaxis. Consequently, routine preoperative prophylaxis is recommended before appendectomy.This publication has 17 references indexed in Scilit:
- Metronidazole and Augmentin in the prevention of sepsis after appendicectomyBritish Journal of Surgery, 1985
- PROPHYLACTIC ANTIBIOTICS IN APPENDICECTOMY: A PROSPECTIVE DOUBLE BLIND RANDOMIZED STUDYAnz Journal of Surgery, 1984
- Prevention of post-appendicectomy sepsis by mezlocillin and metronidazole: a prospective, randomized, double-blind trialJournal of Antimicrobial Chemotherapy, 1984
- A Danish multicenter study: Cefoxitin versus ampicillin + metronidazole in perforated appendicitisBritish Journal of Surgery, 1984
- Prophylaxis of postappendicectomy sepsis by metronidazole and cefotaxime; a randomized, prospective and double blind trialBritish Journal of Surgery, 1983
- Prophylaxis of post-appendicectomy sepsis by metronidazole and ampicillin: A randomized, prospective and double-blind trialBritish Journal of Surgery, 1983
- Effect of Prophylactic Antibiotics in Acute Nonperforated AppendicitisAnnals of Surgery, 1981
- Prophylactic metronidazole in appendicectomy: A controlled trialBritish Journal of Surgery, 1980
- THE PREVENTION OF POST‐APPENDICECTOMY SEPSIS BY METRONIDAZOLE AND CEFAZOLIN: A CONTROLLED DOUBLE BLIND TRIAL6Anz Journal of Surgery, 1980
- One-dose antibiotic prophylaxis against wound infection after appendicectomy: A randomized trial of clindamycin, cefazolin sodium and a placeboBritish Journal of Surgery, 1979