Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials
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- 8 March 2012
- journal article
- research article
- Published by SAGE Publications in Journal of Psychopharmacology
- Vol. 26 (7), 994-1002
- https://doi.org/10.1177/0269881112439253
Abstract
Assessments of lysergic acid diethylamide (LSD) in the treatment of alcoholism have not been based on quantitative meta-analysis. Hence, we performed a meta-analysis of randomized controlled trials in order to evaluate the clinical efficacy of LSD in the treatment of alcoholism. Two reviewers independently extracted the data, pooling the effects using odds ratios (ORs) by a generic inverse variance, random effects model. We identified six eligible trials, including 536 participants. There was evidence for a beneficial effect of LSD on alcohol misuse (OR, 1.96; 95% CI, 1.36–2.84; p = 0.0003). Between-trial heterogeneity for the treatment effects was negligible (I2 = 0%). Secondary outcomes, risk of bias and limitations are discussed. A single dose of LSD, in the context of various alcoholism treatment programs, is associated with a decrease in alcohol misuse.Keywords
This publication has 31 references indexed in Scilit:
- Pilot Study of Psilocybin Treatment for Anxiety in Patients With Advanced-Stage CancerArchives of General Psychiatry, 2011
- Drug harms in the UK: a multicriteria decision analysisThe Lancet, 2010
- Assessment of addiction severity among ritual users of ayahuascaDrug and Alcohol Dependence, 2010
- Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studiesJournal of Psychopharmacology, 2010
- The Pharmacology of Lysergic Acid Diethylamide: A ReviewCNS Neuroscience & Therapeutics, 2008
- Human hallucinogen research: guidelines for safetyJournal of Psychopharmacology, 2008
- Treatment of Alcoholism Using Psychedelic Drugs: A Review of the Program of ResearchJournal of Psychoactive Drugs, 1998
- Residential Psychedelic (LSD) Therapy for the Narcotic AddictArchives of General Psychiatry, 1973
- A Controlled Study of LSD Treatment in Alcoholism and NeurosisThe British Journal of Psychiatry, 1970
- LYSERGIC ACID DIETHYLAMIDE AS A VARIABLE IN THE HOSPITAL TREATMENT OF ALCOHOLISMJournal of Nervous & Mental Disease, 1970