CELL-MEDIATED IMMUNITY AND BLOCKING SERUM ACTIVITY TO TOLERATED ALLOGRAFTS IN RATS

Abstract

W/Fu rats were neonatally inoculated with bone marrow cells from B/N rats and vice versa. Of the inoculated rats, some were capable of accepting a foreign (B/N or W/Fu) skin graft over the period of observation (i.e. for more than 100 days), while other rats rejected their skin grafts as early as control animals (within 8–12 days) or after a prolonged period of acceptance (20–96 days).