Phase II study of high-dose tamoxifen (NSC-180973) in patients with disseminated malignant melanoma
- 1 April 1982
- Vol. 49 (7), 1353-1354
- https://doi.org/10.1002/1097-0142(19820401)49:7<1353::aid-cncr2820490707>3.0.co;2-4
Abstract
Seventeen patients with disseminated malignant melanoma received a daily oral regimen of tamoxifen, 100 mg/m2. All patients had prior chemotherapy and predominantly visceral involvement. None of the patients had an objective regression and most (71%) had progressive disease at the time of first reassessment. Moderate to severe nausea occurred in 24% of patients. In the dose and schedule used in this study, tamoxifen is ineffective in patients with advanced malignant melanoma and prior chemotherapy exposure.This publication has 12 references indexed in Scilit:
- Estrogen receptors in patients with malignant melanomaCancer, 1980
- Sex steroid receptor analysis in human melanomaCancer, 1980
- Tamoxifen in advanced breast cancerCancer Treatment Reviews, 1978
- Estrogen ReceptorsPublished by American Medical Association (AMA) ,1977
- Tamoxifen (Antiestrogen) Therapy in Advanced Breast CancerAnnals of Internal Medicine, 1977
- ŒSTROGEN RECEPTORS IN HUMAN MALIGNANT MELANOMAThe Lancet, 1976
- Anti-Oestrogen Therapy of Advanced Mammary CarcinomaActa Radiologica: Therapy, Physics, Biology, 1976
- A dose response evaluation of delta‐1‐testololactone in advanced breast cancerCancer, 1974
- A dose-response evaluation of androgens in the treatment of metastatic breast cancerCancer, 1973
- Malignant MelanomaBMJ, 1955