Anomeric Specificity of Glucose-Stimulated Insulin Release: Evidence for a Glucoreceptor?
- 8 November 1974
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 186 (4163), 536-538
- https://doi.org/10.1126/science.186.4163.536
Abstract
The effects on insulin secretion of α and β anomers of D-glucose were studied in the in vitro perfused rat pancreas. Both phases of insulin release showed consistent stereospecificity for α-glucose; this specificity indicates an action of glucose independent of intracellular glucose metabolism.Keywords
This publication has 12 references indexed in Scilit:
- Beta Cell Protection to Alloxan Necrosis by Anomers of D-GlucoseScience, 1974
- A threshold distribution hypothesis for packet storage of insulin and its mathematical modelingJournal of Clinical Investigation, 1972
- Decreased Sensitivity of the Pancreatic Beta Cells to Glucose in Prediabetic and Diabetic Subjects: A Glucose Dose-Response StudyDiabetes, 1972
- Kinetics of Insulin Release from the Perfused Rat Pancreas Caused by Glucose, Glucosamine, and GalactoseProceedings of the National Academy of Sciences, 1971
- Enzymes of glucose metabolism in normal mouse pancreatic isletsBiochemical Journal, 1970
- Dynamics of Insulin Secretion by the Perfused Rat PancreasEndocrinology, 1968
- Effect of pulse administration of glucose or glucagon on insulin secretion in vitroMetabolism, 1967
- A method for measuring deviations from equilibrium of the glucose anomers in bloodJournal of Applied Physiology, 1965
- Spontaneous and Enzymatically Catalyzed Anomerization of Glucose 6-Phosphate and Anomeric Specificity of Related EnzymesJournal of Biological Chemistry, 1965
- Kinetics and Distribution of Mutarotases and Their Relation to Sugar TransportJournal of Biological Chemistry, 1964