EFFECT OF THYROXJNE AND RELATED COMPOUNDS ON MONOAMINE OX1DASE ACTIVITY1
- 1 February 1960
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 66 (2), 311
- https://doi.org/10.1210/endo-66-2-311
Abstract
The activity of monoamine oxidase (MO) was studied in the liver, heart and brain of rats. The specific activity of heart was found to be 1.5 [mu]moles tyramine consumed/mg.N/hr.; that of brain 0.9, as compared to about 6.0 for liver. After a daily injection of thyroxine, triiodothyronine and triiodothyroacetic acid, on the 11th day the MO activity of liver was found to be decreased by about 50%. O-Methylthyroxine and thyroxamine caused a decrease of 30 and 25%, respectively. No significant changes in MO activity were noted in heart and brain.Keywords
This publication has 3 references indexed in Scilit:
- Monoamine oxidase activity in liver of thyroid-fed ratsArchives of Biochemistry and Biophysics, 1959
- OXIDATIVE METABOLISM OF HEART MITOCHONDRIAJournal of Biological Chemistry, 1952
- INTRACELLULAR DISTRIBUTION OF ENZYMES .3. THE OXIDATION OF OCTANOIC ACID BY RAT LIVER FRACTIONS1948