The effect of temperature on the tensile strength and disintegration of paracetamol and oxytetracycline tablets
- 1 September 1977
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 29 (1), 389-392
- https://doi.org/10.1111/j.2042-7158.1977.tb11350.x
Abstract
The tensile strengths and disintegration times of paracetamol and oxytetracycline tablets at room temperature are higher when they have been prepared at high temperatures, e.g. 85°, than at room temperature or below, e.g. —20°. The activation energies of the two materials, 3 and 1 k cal mol−1 (13 and 4 kJmol−1) respectively, were derived from plots of log tensile strength and log disintegration time versus the reciprocal of the absolute temperature. The results have been explained in terms of sintering theory and the formation of welded bonds between particles.Keywords
This publication has 11 references indexed in Scilit:
- The tensile strength and disintegration of griseofulvin tabletsPowder Technology, 1977
- Some formulation factors affecting the tensile strength, disintegration and dissolution of uncoated oxytetracycline tabletsJournal of Pharmacy and Pharmacology, 1976
- Temperature changes occurring during the compression and recompression of solidsJournal of Pharmacy and Pharmacology, 1970
- The effect of temperature and compression on the cohesive properties of particulate solidsMaterials Science and Engineering, 1970
- Thermodynamic Effects in the Compression of SolidsJournal of Pharmaceutical Sciences, 1968
- Physics of Tablet Compression XV. Thermodynamic and Kinetic Aspects of Adhesion Under PressureJournal of Pharmaceutical Sciences, 1968
- An improved apparatus for measuring the tensile strength of powdersJournal of Scientific Instruments, 1964
- The physics of tablet compression. VII. Determination of energy expenditure in the tablet compression processJournal of the American Pharmaceutical Association (Scientific ed.), 1955
- The dependence of the melting point on the pressureCzechoslovak Journal of Physics, 1953
- Measurement of Self-Diffusion of Silver without Radioactive TracersJournal of Applied Physics, 1950