Abstract
The tensile strengths and disintegration times of paracetamol and oxytetracycline tablets at room temperature are higher when they have been prepared at high temperatures, e.g. 85°, than at room temperature or below, e.g. —20°. The activation energies of the two materials, 3 and 1 k cal mol−1 (13 and 4 kJmol−1) respectively, were derived from plots of log tensile strength and log disintegration time versus the reciprocal of the absolute temperature. The results have been explained in terms of sintering theory and the formation of welded bonds between particles.