Abstract
EARLIER work from this laboratory showed that certain beef-pineal extracts reversed some of the biochemical abnormalities encountered in schizophrenic patients.1 Clinical improvement also was noted in those earlier studies; this finding accorded with that previously reported by other authors who had used pineal extracts in schizophrenia.2 This report describes some effects of several different aqueous extracts made from acetone-dried beef pineal glands.ObservationsEffects of Simple Aqueous Extracts Alone (Improvement Followed by Refractoriness)An extract was made by mixture of the powder derived from acetone-dried beef-pineal substance with distilled water in a Waring blendor, 10 ml. of water for each . . .

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