Synthesis of trans-2,6-dialkylpiperidines by 1,3-cycloaddition of alkenes to 2-alkyl-2,3,4,5-tetrahydropyridine oxides

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Abstract
A convenient route to trans-2,6-dialkylpiperidines by cycloaddition of alkenes to 2-alkyl-2,3,4,5-tetrahydropyridine oxides followed by reductive cleavage of the resulting isoxazolidine is illustrated by a synthesis of the fire ant-venom alkaloid, solenopsin.