Synthesis and Metabolism of 3alpha, 12alpha-Dihydroxy-delta6-cholenic Acid-24-14C. Bile Acids and Steroids 117.

Abstract

3[alpha], 12 [alpha]-dihydroxy-[DELTA]6-cholenic acid-24-I4C has been synthesized from cholic acid-24-14C. The metabolism of the former acid has been studied after intraperitoneal or intracecal injection to bile duct cannulated rats. The unsaturated acid is reduced in the intestine to deoxycholic acid, which is further oxidized to 12-ketolithocholic acid. Labelled deoxycholic and cholic acids were present in the bile. No transformation of 3[alpha], 12[alpha]-dihydroxy-[DELTA] 5 -cholenic acid occurs in the liver.