COAGULATION OF BLOOD

Abstract

Repeated subcutaneous injections of Ca gluconate were given to 2 dogs after cholecystectomy and ligation of common duct; single intravenous injections of Ca gluconate to 5 normal dogs and of CaCU to 1 normal dog; glucose intravenously to 21 normal and 5 jaundiced dogs; Ca gluconate and glucose to 2 jaundiced dogs; and glucose to 2 dogs after hepatectomy. The results of administration of glucose to 6 jaundiced patients are also mentioned. It would seam that except in very rare instances ionized Ca does not favorably affect the coagulation time of the blood of normal or jaundiced dogs. Glucose, on the other hand, given by mouth or intravenously does favorably affect the coagulation time in both types of animals in the majority of instances. Glucose causes a reduction in the coagulation time in patients with obstructive jaundice when the liver damage is not beyond the stage of partial repair. Glucose has no effect on the coagulation time after hepatectomy. Given to both the normal and jaundiced dog, glucose causes no increase in the blood fibrinogen.