Passive-Active Immunization with Tetanus Immune Globulin (Human)

Abstract

THE ease and efficiency of establishing active immunity against tetanus is universally acknowledged. In groups fifty years of age and over, especially in females, greater efforts must be made by all concerned so that immunization itself will become truly universal, since passive or passive-active immunization after injury in the nonimmune are poor substitutes for active protection acquired before exposure. There will always be circumstances, however, in which it will be desirable to give passive protection to the immunized because of the seriousness of the injury — for example, deep puncture wounds with or without massive contamination, compound fractures, shock and . . .