Response of the Electrical Activity, Motor Activity and Acid Secretion of the Human Stomach to Pentagastrin and Histamine Stimulation

Abstract

The electrical and motor activity and the acid output of the stomach have been studied in 21 subjects at rest, and during stimulation with pentagastrin or histamine. All three parameters were increased by pentagastrin. Intravenous pentagastrin increased acid output at 0.06 μg/kg/h and electrical and motor activity at 0.6 μg/kg/h. The mean maximal rise in frequency of the electrical activity was 20 per cent. The coupling of the electrical and motor activity was augmented. Histamine increased the acid output but had no effect on electrical or motor activity.