Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007 – 2008
- 11 June 2009
- journal article
- review article
- Published by Informa Healthcare in Expert Opinion on Therapeutic Patents
- Vol. 19 (7), 943-956
- https://doi.org/10.1517/13543770902862180
Abstract
Acetyl-CoA carboxylase (ACC) is a biologic target that is receiving increased attention for the treatment of obesity and type 2 diabetes mellitus. Inhibition of this enzyme, either in transgenic mice or pharmacologically, has been shown to have beneficial effects on lab animals. This review of the ACC inhibitor patent literature covers the period from mid-2007 to December 2008, during which time a total of 18 patents were published. These published patent applications include ACC inhibitors that inhibit the enzyme through modulation of the carboxyltransferase-domain, inhibitors that bind to the biotin carboxylase-domain and novel chemotypes whose mode of action was not disclosed. Furthermore, published patents claim the discovery of ACC2 isoform selective and ACC1/2 non-selective inhibitors.Keywords
This publication has 13 references indexed in Scilit:
- Inhibitors of Mammalian Acetyl-CoA CarboxylaseRecent Patents on Cardiovascular Drug Discovery, 2007
- Phenoxy thiazole derivatives as potent and selective acetyl-CoA carboxylase 2 inhibitors: Modulation of isozyme selectivity by incorporation of phenyl ring substituentsBioorganic & Medicinal Chemistry Letters, 2007
- The synthesis and structure–activity relationship studies of selective acetyl-CoA carboxylase inhibitors containing 4-(thiazol-5-yl)but-3-yn-2-amino motif: Polar region modificationsBioorganic & Medicinal Chemistry Letters, 2007
- Hepatic De Novo Lipogenesis Is Present in Liver-Specific ACC1-Deficient MiceMolecular and Cellular Biology, 2007
- Structure–activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activityBioorganic & Medicinal Chemistry Letters, 2006
- Acetyl‐coenzyme A carboxylases: Versatile targets for drug discoveryJournal of Cellular Biochemistry, 2006
- Synthesis and Structure−Activity Relationships of N-{3-[2-(4-Alkoxyphenoxy)thiazol-5-yl]-1- methylprop-2-ynyl}carboxy Derivatives as Selective Acetyl-CoA Carboxylase 2 InhibitorsJournal of Medicinal Chemistry, 2006
- Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethalProceedings of the National Academy of Sciences, 2005
- Crystal Structure of the Carboxyltransferase Domain of Acetyl-Coenzyme A Carboxylase in Complex with CP-640186Structure, 2004
- Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental AnimalsJournal of Biological Chemistry, 2003