Two drug addicts who practiced s.c. injection of crushed tripelennamine and pentazocine tablets, a practice known as skin-popping, developed nephrotic syndrome and showed amyloidosis on renal biopsy. The patients had chronic inflammation of the skin in the form of abscesses and ulcerations. Both patients were long-standing drug abusers but had practiced intradermal drug administration for only 3 yr. The occurrence of amyloidosis in these patients appears to relate to their particular drug habit and must be considered in the differential diagnosis of proteinuria in this patient population.