EFFET DE L'HORMONE ADRÉNOCORTICO-TROPE SUR LA MORPHOLOGIE DU CORTEX SURRÉNALIEN, SON CONTENU EN ACIDE ASCORBIQUE ET EN ESTERS DE CHOLÉSTEROL CHEZ LE RAT NORMAL

Abstract

Injn. of a single dose of ACTH (2 mg./100g. body wt.) causes an increase in wt. and vol. of the suprarenals, with macroscopically visible degranulation, a sharp but transitory fall in suprarenal ascorbic acid, and a slower fall in cholesterol esters. Histologically, there was a diminution of sudanophilia, less marked in the glomerular than in the other cortical zones, and a decrease in ascorbic acid, especially in the inferior reticular zone, through which accumulation of ascorbic acid chiefly takes place. The histological and chemical modifications produced by ACTH are much less marked in the glomerular than in the other cortical zones. This difference applies both to the cholesterol and ascorbic acid content.