Evidence That Triiodothyronine and Reverse Triiodothyronine Are Sequentially Deiodinated in Man*
- 1 June 1978
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 46 (6), 916-922
- https://doi.org/10.1210/jcem-46-6-916
Abstract
We have demonstrated that in patients given a single iv injection of T3, rT3, or, to a lesser extent, T4, all labeled with 125I in the outer or phenolic ring, chromatography of serum on columns of Sephadex G-25 superfine revealed the presence of a labeled material, separate from the administered hormone and from both iodide and iodoprotein. This peak has been termed pre-T3 because it elutes just before the T3 peak. Identification of the various compounds in pre-T3 was carried out by cation exchange chromatography. Pre-T3 generated from [125I]T3 consistently contained labeled compounds with the chromatographic behavior of 3,3′-diiodothyronine and 3′-monoiodothyronine, while pre- T.j generated from [l25I]rT3 contained labeled products with the chromatographic mobility of 3′,5′-diiodothyronine, 3,3'-diiodothyronine, and 3′-monoiodothyronine. In addition, pre-T3) also contained the glucuro- and sulfoconjugates of these several labeled products. These studies demonstrate that T3 and rT3.) undergo progressive and probably sequential deiodination in the peripheral tissues, resulting in the formation of a variety of diiodothyronines and monoiodothyronine, as well as their glucuro- and sulfoconjugates.Keywords
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