Platelet Activation: a New Biological Activity of Guinea‐pig C3a Anaphylatoxin
- 1 February 1978
- journal article
- research article
- Published by Wiley in Scandinavian Journal of Immunology
- Vol. 7 (2), 173-180
- https://doi.org/10.1111/j.1365-3083.1978.tb00441.x
Abstract
3H-serotonin-release from labeled gp[guinea pig]-platelets is established as a sensitive method for testing a new biological activity of gp-C3a anaphylatoxin in an autologous situation. Time-, dose- and temperature-dependent release reactions as well as specific inhibition by carboxypeptidase B and anti-C3a antibodies show that C3a is a potent and specific inducer of platelet activation. Inactive C3a does not induce 3H-serotonin-release but specifically inhibits the action of C3a on platelets.This publication has 20 references indexed in Scilit:
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