MONOCLONAL ANTIBODIES AGAINST Rh AND Rh RELATED ANTIGENS

Abstract

MAB 114 and MAB 120 appeared to have the same or a very similar specificity to BRIC 125 (Avent et al., 1988). MAB 116, and possibly MAB 115, had a similar specificity to R6A (Anstee & Edwards, 1982; Avent et al., 1988). MAB 117, 118 and 119 demonstrated the MB-2D10 specificity and were, in fact, the antibodies reported by von dem Borne et al. (1990). MAB 121 was not anti-Rh34-like since it reacted with RH: 34 red cells. MAB 122 was not anti-HR since it reacted with RH: 18 cells. The specificities of MAB 121 and MAB 122 were not identified and although they probably detect different epitopes insufficient MAB 122 was available to confirm this suspicion. None of the MABS tested appeared to have the same specificity as 1D8 (Miller et al., 1987) or BS58 (Sonneborn et al., 1990). Competitive binding studies with MAB 121 provided evidence of a close association of BRIC 125 polypeptide with Rh polypeptides.