Antagonism of GABA by picrotoxin in the feline cerebral cortex
Open Access
- 1 April 1972
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 44 (4), 807-809
- https://doi.org/10.1111/j.1476-5381.1972.tb07319.x
Abstract
Picrotoxin and gamma-aminobutyric acid (GABA) were applied by microiontophoresis to an unselected population of neurones in the feline cerebral cortex. Picrotoxin was shown to antagonize the depressant effects of GABA and in addition appeared free of some of the actions of bicuculline which tend to mask GABA antagonism.Keywords
This publication has 13 references indexed in Scilit:
- THE EFFECT OF BICUCULLINE, METRAZOL, PICROTOXIN AND STRYCHNINE ON THE RELEASE OF [3H]GABA FROM RAT BRAIN SLICESJournal of Neurochemistry, 1971
- The effect of bicuculline on the gamma-aminobutyric acid (GABA) receptors of neurones of Periplaneta americana and Helix aspersaBrain Research, 1971
- Antagonism between bicuculline and GABA in the cat brainBrain Research, 1971
- Evaluation of Bicuculline as a GABA AntagonistNature, 1971
- Iontophoretic studies in deiter's nucleus of the inhibitory actions of GABA and related amino acids and the interactions of strychnine and picrotoxinBrain Research, 1971
- Doubtful Value of Bicuculline as a Specific Antagonist of GABANature, 1970
- Glutamate and γ-Aminobutyric Acid in BrainNature, 1970
- On the interaction of picrotoxin with GABA and glycine in the spinal cordBrain Research, 1970
- GABA-picrotoxin interaction in the mammalian central nervous systemBrain Research, 1969
- Pharmacology of cortical inhibitionThe Journal of Physiology, 1966