Self-Administration of Pralidoxime in Nerve Gas Poisoning with A Note on the Stability of the Drug
- 1 September 1963
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 15 (1), 671-677
- https://doi.org/10.1111/j.2042-7158.1963.tb12859.x
Abstract
Plasma concentrations of pralidoxime methane sulphonate (P2S) have been determined in man after self-administration by an automatic injector. After administration of 10 mg./kg. P2S in a 50 per cent w/v solution, concentrations over 4 μg./ml. were reached within 6 min. and maintained for about 90 min. After 20 mg./kg., plasma concentrations over 4 μg./ml. were maintained for about 170 min. Except for pain at the site of injection, which disappeared after a few hr., no serious side reactions could be detected. The drug can be stored for 5 years at 5° with less than 7 per cent decomposition. The decomposition products were found to be less toxic than the unchanged oxime. N-Methylpyridinium-2-carboxamide was identified as a major degradation product.Keywords
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