DimethylanilineN-Oxidase and AminopyrineN-Demethylase Activities of Human Liver Tissue
- 1 January 1973
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 3 (3), 179-189
- https://doi.org/10.3109/00498257309151512
Abstract
1. N-Oxidation of N,N-dimethylaniline and oxidative demethylation of aminopyrine were studied in human liver hornogenates. At their respective pH optima (8·4 for N-oxidase and 7·4 for demethylase) N-oxidase activity was higher than that of demethylase in the majority of biopsies assayed. 2. Neither activity was preferentially influenced by a specific disease process, but both decreased upon severe tissue damage. There was no apparent relationship of either activity with age or sex. 3. Demethylase activities were highest in patients exposed to barbiturates, and increased N-oxidase activity was observed in patients exposed to amphetamines and some tranquilizers.Keywords
This publication has 17 references indexed in Scilit:
- Studies on drug metabolism in human liverChemico-Biological Interactions, 1971
- N-Oxide Formation and Related Reactions in Drug MetabolismXenobiotica, 1971
- Estimation of amine oxides in the presence of hepatic microsomesBiochemical and Biophysical Research Communications, 1970
- Human liver microsomal drug metabolismBiochemical Pharmacology, 1970
- Effects of various in vitro conditions on hepatic microsomal N- and C-oxygenation of aromatic aminesChemico-Biological Interactions, 1970
- Urinary metabolites of 10-[3'-(4″-methyl-piperazinyl)-propyl]-phenothiazine (perazine) in psychiatric patients—IBiochemical Pharmacology, 1969
- Hepatic Microsomal Enzymes in Man and Rat: Induction and Inhibition by EthanolScience, 1968
- Ethanol Increases Hepatic Smooth Endoplasmic Reticulum and Drug-Metabolizing EnzymesScience, 1968
- Formation of an intermediate N-oxide in the oxidative demethylation of N,N-dimethylaniline catalyzed by liver microsomesBiochemical and Biophysical Research Communications, 1964
- Species, strain and sex differences in metabolism of hexobarbitone, amidopyrine, antipyrine and anilineBiochemical Pharmacology, 1958