Fabrication of Magnetic Core@Shell Fe Oxide@Au Nanoparticles for Interfacial Bioactivity and Bio-separation
- 13 July 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Langmuir
- Vol. 23 (17), 9050-9056
- https://doi.org/10.1021/la701305f
Abstract
The immobilization of proteins on gold-coated magnetic nanoparticles and the subsequent recognition of the targeted proteins provide an effective means for the separation of proteins via application of a magnetic filed. A key challenge is the ability to fabricate such nanoparticles with the desired core−shell nanostructure. In this article, we report findings of the fabrication and characterization of gold-coated iron oxide (Fe2O3 and Fe3O4) core@shell nanoparticles (Fe oxide@Au) toward novel functional biomaterials. A hetero-interparticle coalescence strategy has been demonstrated for fabricating Fe oxide@Au nanoparticles that exhibit controllable sizes ranging from 5 to 100 nm and high monodispersity. Composition and surface analyses have proven that the resulting nanoparticles consist of the Fe2O3 core and the Au shell. The magnetically active Fe oxide core and thiolate-active Au shell were shown to be viable for exploiting the Au surface protein-binding reactivity for bioassay and the Fe oxide core magnetism for magnetic bioseparation. These findings are entirely new and could form the basis for fabricating magnetic nanoparticles as biomaterials with tunable size, magnetism, and surface binding properties.Keywords
This publication has 27 references indexed in Scilit:
- Laser-Assisted Synthesis of Superparamagnetic Fe@Au Core−Shell NanoparticlesThe Journal of Physical Chemistry B, 2006
- Magnetic nanoparticles for drug deliveryDrug Development Research, 2006
- Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery systemJournal of Magnetism and Magnetic Materials, 2005
- Magnetic separation of amino acids by gold/iron-oxide composite nanoparticles synthesized by gamma-ray irradiationJournal of Magnetism and Magnetic Materials, 2005
- Advances in magnetic nanoparticles for biotechnology applicationsJournal of Magnetism and Magnetic Materials, 2004
- Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and NanotechnologyChemical Reviews, 2003
- Femtomolar Detection of Prostate-Specific Antigen: An Immunoassay Based on Surface-Enhanced Raman Scattering and Immunogold LabelsAnalytical Chemistry, 2003
- Nanoparticles, Proteins, and Nucleic Acids: Biotechnology Meets Materials ScienceAngewandte Chemie International Edition, 2001
- Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brainJournal of Magnetism and Magnetic Materials, 2001
- Monodispersed Colloidal Spheres: Old Materials with New ApplicationsAdvanced Materials, 2000