Effects of Lysergic Acid Diethylamide upon Performance of Trained Rats
- 1 June 1956
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 92 (2), 285-289
- https://doi.org/10.3181/00379727-92-22453
Abstract
A syndrome resulting from intraperitoneal injection of lysergic acid diethylamide (LSD) in rats is described. In rats trained to climb a rope, LSD produces signs of confusion and markedly prolongs climbing time. This effect on climbing time can be objectively and quantitatively measured, and is linearly related to the log dose of LSD. Effects of LSD could be partially antagonized by serotonin or by 5-hydroxy tryptophane given intraperitoneally. [alpha]-4(Piperidyl) benzhydrol did not affect the action of LSD, while reserpine intensified and prolonged the LSD-syndrome.Keywords
This publication has 3 references indexed in Scilit:
- Interaction of serotonin and lysergic acid diethylamide (LSD) in the central nervous systemCellular and Molecular Life Sciences, 1955
- PRODUCTION OF ABNORMAL (PSYCHOTIC?) BEHAVIOR IN MICE WITH LYSERGIC ACID DIETHYLAMIDE, AND ITS PARTIAL PREVENTION WITH CHOLINERGIC DRUGS AND SEROTONINProceedings of the National Academy of Sciences, 1955
- STUDIES ON HEPTAZONE (6-MORPHOLINO-4,4-DIPHENYL-3-HEPTANONE HYDROCHLORIDE) IN COMPARISON WITH OTHER ANALGESIC DRUGS1950