Effect of Rifampicin on Delayed-Hypersensitivity Reactions

Abstract

Rifampicin inhibits the blastic transformation of lymphocytes cultured in the presence of phytohemoagglutinin. It also inhibits the tuberculin reaction in guinea pigs and rats inoculated with Freund's complete adjuvant. The significance of the interference of rifampicin in delayed-hypersensitivity reactions remains to be assessed.