PITUITARY MYXEDEMA: REPORT OF THREE CASES

Abstract

Three cases are reported of patients, whose histories and physical findings were fairly typical of myxedema, but who on further study were found to be instances of primary anterior pituitary insufficiency, with secondary hypothyroidism, hypogonadism, and adrenocortical insufficiency. Each patient was found to have a pituitary tumor, presumably a chromophobe adenoma. Hypogonadism is the most prominent clinical feature distinguishing these cases from primary myxedema. In each case the pituitary tumor was irradiated and secondary glandular replacement given with desiccated thyroid, testosterone, desoxycorticosterone acetate, and supplementary salt. The amt. of each needed has to be detd. by careful trial and observation. Results of treatment are considered quite good in 2 cases, while the third patient was only partially restored to health. The 3d patient had a complicating mitral stenosis which limited the amt. of desoxycorticosterone and salt therapy that could be given.