Superoxide generation by either 1‐oleoyl‐2‐acetylglycerol or A23187 in human neutrophils is enhanced by indomethacin
- 3 June 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 185 (1), 213-217
- https://doi.org/10.1016/0014-5793(85)80772-9
Abstract
Indomethacin at a concentration (1O−4 M) which depressed the effect on O2 − generation by fMet-Leu-Phe, markedly enhanced O2 −, generation by both 1-oleoyl-2-acetylglycerol and the calcium ionophore, A23187. These results are explicable in terms of the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in signal transduction for the respiratory burst in the human neutrophil.Keywords
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