A Method of Studying the Modification by Drugs of the Oxidation-Reduction Systems of the Skin
- 1 September 1954
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 6 (1), 178-186
- https://doi.org/10.1111/j.2042-7158.1954.tb10934.x
Abstract
Summary: A new method is described for studying the modification by drugs of the oxidation-reduction systems of the skin in man. This consists in noting the changes produced in the decolorisation time of a standard intradermal wheal made with 2:6-dichlorophenol indophenol indicator solutions. The decolorisation time is significantly decreased by ascorbic acid and by glutathione, and increased by adrenocorticotrophic hormone and cortisone, when these agents are administered systemically. The significance of the electrode potential (Eh) of the tissues in relation to these findings is discussed.Keywords
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