Intravenous versus superior mesenteric artery vasopressin infusions for the treatment of variceal bleeding.
- 1 March 1982
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 142 (3), 769-772
- https://doi.org/10.1148/radiology.142.3.6977790
Abstract
The effects of 30-min i.v. and superior mesenteric artery (SMA) infusions of vasopressin in dosages of 2.75 mU and 14 mU per min per kg were compared in 5 dogs that had cirrhosis and portal hypertension induced by fractionated intraportal polyvinyl alcohol injections. A reduction in portal pressure of .apprx. 35% was found with both SMA doses and the larger i.v. vasopressin dose, while the smaller i.v. dose reduced portal pressure only 18%. A significantly larger decrease in portal blood flow was found with SMA than i.v. vasopressin administration. Cardiovascular side effects were dose-dependent but independent of the administration mode. Liver enzymes were unaffected. Portal vein thrombosis occurred in 1 dog after the larger SMA dose.This publication has 3 references indexed in Scilit:
- The Effect of Vasopressin on Hepatic Arterial Blood FlowRadiology, 1977
- Reduction of portal venous pressure in cirrhotic patients with bleeding from oesophageal varices, by administration of a vasopressin derivative, phenylalanine2-lysine8-vasopressinAmerican Journal Of Medicine, 1964
- Multiple Infusions of Posterior Pituitary Extract in the Treatment of Bleeding Esophageal VaricesAnnals of Internal Medicine, 1962