This investigation deals with a study of the plastic behavior of anisotropic metals. By extending Hill’s theory of plastic flow of anisotropic metals, plastic stress-strain relations for anisotropic materials with strain hardening are developed. Applications of these relations are also made to plane-stress and plane-strain problems with anisotropy. The effect of anisotropy on the stress distribution and on the pressure to produce yielding in a thick-walled cylinder under internal pressure is discussed. The influence of anisotropy on the interpretation of conventional biaxial tension-tension and tension-torsion tests is also considered in this study.