VIRAL SHEDDING IN CHINESE CHILDREN FOLLOWING VACCINATION WITH HPV-77 AND CENDEHILL-51 LIVE ATTENUATED RUBELLA VACCINES1

Abstract

Detels, R., K. S. W. Kim, J. L. Gale and J. T. Grayston (NAMRU-2, Box 14, APO San Francisco, California 96263). Viral shedding in Chinese children following vaccination with HPV-77 and Cendehill-51 live attenuated rubella vaccines. Amer J Epidem 94: 473–478, 1971.—Throat swab specimens were taken at 3–5 day intervals between the 7th and 50th day after vaccination from 54 of 421 boys receiving Cendehill-51 vaccine and from 34 boys receiving African green monkey kidney (AGMK) vaccine and 35 duck embryo cell culture (DECC) vaccine in another school. The majority of isolations from vaccinees receiving Cendehill-51 were made between the 7th and 16th day, although isolations were made through the 25th day and from two specimens on the 35th day. No natural rubella occurred during the Cendehill study. The majority of isolations from vaccinees receiving the AGMK and DECC vaccines were made between the 14th and 22nd day, but isolations were made through the 49th day when swabbing was terminated. Two isolates were obtained from placebo-vaccinated boys on the 39th and 49th day. Clinical rubella was recognized on the 68th day. Twelve of 31 shedders did not shed beyond the 22nd day. Nine shed only after the 35th day. Ten shed both during and after the previously reported period of maximum shedding. These results were interpreted as showing both occasional shedding of vaccine virus beyond the previously reported extreme of 28 days and failure of rubella vaccine to prevent subclinical infection and shedding of wild virus.