Effects of thioridazine and withdrawal dyskinesias on workshop performance of mentally retarded young adults [retracted in Am J Psychiatry 1989 May;146(5):634]

Abstract

A 2-part study of the effects of thioridazine [a neuroleptic] and withdrawal dyskinesias on the workshop performance of mentally retarded young adults was conducted. In part 1, 80 mentally retarded subjects were divided into 5 groups of 16 according to administration, discontinuation or nonadministration of thioradazine. The major finding was that thioridazine can impair the workshop performance of mentally retarded individuals. In part 2, 28 subjects were divided into 4 matched groups of 7 subjects each whose thioridazine dose was abruptly or gradually discontinued and who did or did not have withdrawal dyskinesias. Workshop performance declined with the onset of the dyskinesias and improved as the dyskinesias subsided.