High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients
Open Access
- 14 June 2013
- journal article
- Published by Springer Nature in BMC Cancer
- Vol. 13 (1), 1-288
- https://doi.org/10.1186/1471-2407-13-288
Abstract
Vulvar squamous cell carcinoma is a cancer form with increasing incidence rate and few treatment options. Wee1 is a central regulator of the G2/M DNA-damage checkpoint, and has in previous studies been described as a prognostic biomarker and a potential target for therapy in other cancer forms.Keywords
This publication has 32 references indexed in Scilit:
- High Expression of Wee1 Is Associated with Poor Disease-Free Survival in Malignant Melanoma: Potential for Targeted TherapyPLOS ONE, 2012
- Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferationCancer Biology & Therapy, 2011
- Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replicationNucleic Acids Research, 2011
- Role of TP53 Mutations in Vulvar CarcinomasInternational Journal of Gynecological Pathology, 2011
- Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypesBMC Cancer, 2010
- Integrated Functional, Gene Expression and Genomic Analysis for the Identification of Cancer TargetsPLOS ONE, 2009
- Trends in the Incidence of Invasive and In Situ Vulvar CarcinomaObstetrics & Gynecology, 2006
- Cyclins D1, D3, E, and A in vulvar carcinoma patientsGynecologic Oncology, 2005
- p16INK4a and p21Waf1/Cip1 expression correlates with clinical outcome in vulvar carcinomasGynecologic Oncology, 2004
- The clinical significance of Cyclin B1 and Wee1 expression innon-small-cell lung cancerAnnals of Oncology, 2004